Now That's What I Call Music! 33 was released on March 23, 2010. The album is the 33rd edition of the (U.S.) Now! series. Two of the tracks featured on Now! 33, "Tik Tok" and "Fireflies", reached number one on the Billboard Hot 100. The final five tracks are considered "What's Next New Music Preview" bonus tracks.

In its first week of release, it sold 135,000 copies to debut at number three on the Billboard 200 albums chart.